Today, we launch a new initiative aimed at overcoming one of the toughest problems in finding preventions, treatments and cures for orphan, rare and neglected (ORN) diseases…crossing the chasm from protein target to drug candidate molecule. Traditionally, this step requires screening many potentially active molecules – a time consuming and expensive process. That’s because until now, researchers had few alternatives; either they used less selective computational tools, and settled for longer lists of molecules that held less promise, or they consumed time and resources in high throughput screening, hoping to find a good candidate to take onward into development.
Starting now, researchers and those committed to preventing, treating and curing ORN diseases have a powerful tool – Inverse Design™. Quantum Cures Foundation will provide this computational tool to research organizations free of charge. Collaborators will just have to provide us with a protein target having an X-ray structure, and work with us to design some molecular starting points (we call them “scaffolds”). Then, we will use the power of donated computer time to design new drug and vaccine candidate molecules.
Please…if you, or someone you know is involved in ORN disease research, spread the word. Quantum Cures wants to help.
Lawrence Husick, Exton, PA, US, 28-FEB-13 (International Rare Disease Day!)